Alright, I want to know: How fast would this get me kicked out of a venue for running it?

WM005 Dr. Manhattan 276
Elite Sniper 20
GX036 Professor X 123
WS003 Researcher x5 75 total
Scorpio Key 4
Total: 498

Map choice is Madripoor, starting at the water end

Wouldn't get you kicked out of mine. It's a brutal team but I've seen far more efficient teams at that point value. Heck just think about the dangers of a tabitha smith with armor piercing.... :D

Why go more than 3 researchers? The rule of 3 makes it a little pointless.

Some for Manhattan and some for Prof. X. Or if I put 3 next to Manhattan and I use X through Manhattan would Manhattan's Researchers work for X too?

Nope, the researchers would have to be adjacent to Professor X. though you have 5 of them so that should'nt be too much of a problem